7-Hydroxymitragynine Legality: State-by-State Guide 2026

“Similarly, with kratom—while not nearly as potent as a stimulant—it is unusual that it also acts like an opioid when taken at a higher dose.” “Vape stores are popping up in every neighborhood in America, and many are selling addictive products like concentrated 7-OH. In July, the agency also announced steps to restrict 7-OH opioid products threatening American consumers. Florida is the first state to target the highly addictive synthetic, concentrated byproduct. He said those nraes products are not what the kratom community is about.

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• The Southeast Asian herbal product is often taken for an energy boost and has been billed to alleviate pain and anxiety, and ease withdrawal from opioids.
• The kratom inside Clarke’s car was awaiting testing when Clarke died.
• “There should be requirements on what type of packaging, and you should have to have certificate, you know, COAs, and all the same requirements to keep the public safe in the way the products are manufactured and distributed,” she said.
• We recently sat down with Kroll, whose research focuses largely on herbal medicines, to learn more about the issues with the popular-yet-unregulated kratom, often used as an alternative to opioids for pain relief and as a self-therapy for alcohol and opioid addiction.
• Some reports suggest that kratom may be an effective treatment for opioid addiction.
• “We want to save as many people from this evil substance,” said Democratic state Assemblyman Phil Steck.

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Last month, he tried to kick kratom a second time using Ibogaine and said he’s feeling hopeful it will stick. The kratom leaf is harvested from a tropical evergreen tree indigenous to Thailand, Malaysia and Indonesia and imported into the United States. Clarke’s arrest and subsequent death has put a spotlight on kratom, they said, at a time when lawmakers in many states are deciding whether to regulate or ban it. The office would not disclose whether it will test for kratom, though it has screened for the plant’s active components in past death investigations. That amount of kratom wouldn’t be considered excessive or unusual, said Mac Haddow, a senior fellow on public policy for the American Kratom Association, a consumer group that advocates for states to regulate kratom, not ban it.

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“Vape stores are popping up in every neighborhood in America, and many are selling addictive products like concentrated 7-OH,” Makary warned. The synthetic byproduct isn’t legal in dietary supplements or food products. That’s because kratom’s active ingredients — mitragynine and 7-hydroxymitragynine (7-OH) — bind to the same brain receptors as morphine and alcohol, triggering a rush of dopamine, the body’s “feel good hormone.” “These people find it difficult to control their use of kratom and experience opioid-like withdrawal symptoms when they stop.”

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According to agency statements, natural kratom leaf products are not the focus of this action. More recently, bills were introduced this 2025–26 legislative session in states like Delaware, Illinois, Michigan, South Dakota, and Tennessee that would prohibit kratom and kratom products within their boundaries. Last year, California was on its way to having statewide regulation for kratom products. But recently, public health officials have raised alarms about a component of the leaf called hydroxymitragynine, also known as 7-OH, an alkaloid that has the potential for abuse because of its ability to bind to opioid receptors in the body.